Chelsea’s reward in the fourth round for their 7-1 win over Grimsby is a home tie against Manchester United.
The Red Devils needed penalties to overcome League One side Rochdale – after teenagers Marcus Greenwood and Luke Matheson had cancelled each other out.
That is not the only intriguing tie in the last 16 as Arsenal will travel to Liverpool.
The Gunners demolished Nottingham Forest 5-0 on Tuesday night, while Liverpool maturely dispatched of MK Dons.
The two lowest-ranked sides left in the competition, League Two pair Crawley and Colchester, were drawn together.
Elsewhere, Everton will host Watford, Aston Villa will play Wolves and holders Manchester City will have to overcome Southampton in all Premier League ties.
Leicester have the easiest looking fixture on paper as they will travel to Bournemouth conquerers Burton Albion, with Oxford vs Sunderland rounding out the draw.
Carabao Cup 4th Round Draw
Everton vs. Watford
Aston Villa vs. Wolverhampton Wanderers
Manchester City vs. Southampton
Burton vs. Leicester
Crawley vs. Colchester
Chelsea vs. Man United
Oxford vs. Sunderland
Liverpool vs. Arsenal